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Prenatal versus postnatal maternal factors in the development of infection-induced working memory impairments in mice.
- Source :
-
Brain, behavior, and immunity [Brain Behav Immun] 2013 Oct; Vol. 33, pp. 190-200. Date of Electronic Publication: 2013 Jul 20. - Publication Year :
- 2013
-
Abstract
- Prenatal maternal infection is an environmental risk factor for neurodevelopmental psychiatric illness and disease-associated cognitive impairments. Modeling this epidemiological link in animals shows that prenatal immune challenge is capable of inducing long-lasting deficits in numerous cognitive domains. Here, we combined a neonatal cross-fostering design with a mouse model of prenatal immune challenge induced by maternal gestational treatment with the viral mimetic poly(I:C) to dissect the relative contribution of prenatal and postnatal maternal effects on the offspring. We show that offspring prenatally exposed to poly(I:C) display significant impairments in spatial matching-to-position working memory and spatial novelty presence regardless of whether they are raised by gestationally immune-challenged or non-challenged control surrogate mothers. Likewise, prenatally immune challenged offspring exhibit reduced glutamic acid decarboxylase 65-kDa (GAD65) and 67-kDa (GAD67) gene expression in the adult medial prefrontal cortex and dorsal hippocampus largely independently of the postnatal rearing conditions. In addition, we confirm that being raised by a gestationally immune-challenged surrogate mother is sufficient to increase the offspring's locomotor response to systemic amphetamine treatment. Our data thus suggest that prenatal infection-induced deficits in spatial short-term memory are mediated by prenatal maternal effects on the offspring. At the same time, our study adds further weight to the notion that being reared by a surrogate mother that experienced immune activation during pregnancy may constitute a risk factor for specific dopaminergic abnormalities.<br /> (Copyright © 2013 Elsevier Inc. All rights reserved.)
- Subjects :
- Animals
Animals, Newborn immunology
Down-Regulation genetics
Down-Regulation immunology
Female
Glutamate Decarboxylase genetics
Hippocampus enzymology
Hippocampus immunology
Hippocampus pathology
Male
Memory Disorders enzymology
Memory Disorders genetics
Memory Disorders immunology
Mice
Mice, Inbred C57BL
Poly I-C antagonists & inhibitors
Poly I-C toxicity
Postnatal Care
Prefrontal Cortex enzymology
Prefrontal Cortex immunology
Prefrontal Cortex pathology
Pregnancy
Prenatal Diagnosis
Random Allocation
gamma-Aminobutyric Acid genetics
Glutamate Decarboxylase deficiency
Maternal Exposure adverse effects
Subjects
Details
- Language :
- English
- ISSN :
- 1090-2139
- Volume :
- 33
- Database :
- MEDLINE
- Journal :
- Brain, behavior, and immunity
- Publication Type :
- Academic Journal
- Accession number :
- 23876745
- Full Text :
- https://doi.org/10.1016/j.bbi.2013.07.006