Back to Search
Start Over
Local exome sequences facilitate imputation of less common variants and increase power of genome wide association studies.
- Source :
-
PloS one [PLoS One] 2013 Jul 16; Vol. 8 (7), pp. e68604. Date of Electronic Publication: 2013 Jul 16 (Print Publication: 2013). - Publication Year :
- 2013
-
Abstract
- The analysis of less common variants in genome-wide association studies promises to elucidate complex trait genetics but is hampered by low power to reliably detect association. We show that addition of population-specific exome sequence data to global reference data allows more accurate imputation, particularly of less common SNPs (minor allele frequency 1-10%) in two very different European populations. The imputation improvement corresponds to an increase in effective sample size of 28-38%, for SNPs with a minor allele frequency in the range 1-3%.
Details
- Language :
- English
- ISSN :
- 1932-6203
- Volume :
- 8
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- PloS one
- Publication Type :
- Academic Journal
- Accession number :
- 23874685
- Full Text :
- https://doi.org/10.1371/journal.pone.0068604