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Association of mitochondrial genetic variation with carotid atherosclerosis.
- Source :
-
PloS one [PLoS One] 2013 Jul 09; Vol. 8 (7), pp. e68070. Date of Electronic Publication: 2013 Jul 09 (Print Publication: 2013). - Publication Year :
- 2013
-
Abstract
- In human pathology, several diseases are associated with somatic mutations in the mitochondrial genome (mtDNA). Even though mitochondrial dysfunction leads to increased oxidative stress, the role of mitochondrial mutations in atherosclerosis has not received much attention so far. In this study we analyzed the association of mitochondrial genetic variation with the severity of carotid atherosclerosis, as assessed by carotid intima-media thickness (cIMT) and the presence of coronary heart disease (CHD) in 190 subjects from Moscow, Russia, a population with high CHD occurrence. cIMT was measured by high-resolution B-mode ultrasonography and mtDNA heteroplasmies by a pyrosequencing-based method. We found that heteroplasmies for several mutations in the mtDNA in leukocytes, including C3256T, T3336C, G12315A, G13513A, G14459A, G14846A, and G15059A mutations, were significantly (p<0.001) associated with both the severity of carotid atherosclerosis and the presence of CHD. These findings indicate that somatic mitochondrial mutations have a role in the development of atherosclerosis.
- Subjects :
- Aged
Atherosclerosis pathology
Carotid Artery Diseases pathology
Carotid Intima-Media Thickness
Female
Humans
Leukocytes metabolism
Leukocytes pathology
Male
Middle Aged
Mitochondria pathology
Mitochondria ultrastructure
Mutation
ROC Curve
Risk Factors
Atherosclerosis genetics
Carotid Artery Diseases genetics
Genetic Association Studies
Genetic Variation
Genome, Mitochondrial
Subjects
Details
- Language :
- English
- ISSN :
- 1932-6203
- Volume :
- 8
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- PloS one
- Publication Type :
- Academic Journal
- Accession number :
- 23874496
- Full Text :
- https://doi.org/10.1371/journal.pone.0068070