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Lithothamnion muelleri controls inflammatory responses, target organ injury and lethality associated with graft-versus-host disease in mice.
- Source :
-
Marine drugs [Mar Drugs] 2013 Jul 18; Vol. 11 (7), pp. 2595-615. Date of Electronic Publication: 2013 Jul 18. - Publication Year :
- 2013
-
Abstract
- Lithothamnion muelleri (Hapalidiaceae) is a marine red alga, which is a member of a group of algae with anti-inflammatory, antitumor, and immunomodulatory properties. The present study evaluated the effects of treatment with Lithothamnion muelleri extract (LM) in a model of acute graft-versus-host disease (GVHD), using a model of adoptive splenocyte transfer from C57BL/6 donors into B6D2F1 recipient mice. Mice treated with LM showed reduced clinical signs of disease and mortality when compared with untreated mice. LM-treated mice had reduced tissue injury, less bacterial translocation, and decreased levels of proinflammatory cytokines and chemokines (interferon-γ (IFN-γ), tumor necrosis factor-α (TNF-α), chemokine (C-C motif) ligand 2 (CCL2), chemokine (C-C motif) ligand 3 (CCL3) and chemokine (C-C motif) ligand 5 (CCL5)). The polysaccharide-rich fraction derived from LM could inhibit leukocyte rolling and adhesion in intestinal venules, as assessed by intravital microscopy. LM treatment did not impair the beneficial effects of graft-versus-leukaemia (GVL). Altogether, our studies suggest that treatment with Lithothamnion muelleri has a potential therapeutic application in GVHD treatment.
- Subjects :
- Animals
Cell Adhesion immunology
Cell Line
Cytokines immunology
Disease Models, Animal
Endothelial Cells immunology
Intestines immunology
Leukocytes immunology
Liver Diseases immunology
Macrophages immunology
Mice
Mice, Inbred C57BL
Anti-Inflammatory Agents immunology
Graft vs Host Disease immunology
Inflammation immunology
Rhodophyta immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1660-3397
- Volume :
- 11
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Marine drugs
- Publication Type :
- Academic Journal
- Accession number :
- 23873335
- Full Text :
- https://doi.org/10.3390/md11072595