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Dancing the cell cycle two-step: regulation of yeast G1-cell-cycle genes by chromatin structure.
- Source :
-
Trends in biochemical sciences [Trends Biochem Sci] 2013 Sep; Vol. 38 (9), pp. 467-75. Date of Electronic Publication: 2013 Jul 16. - Publication Year :
- 2013
-
Abstract
- The chromatin structure at a promoter can define how a gene is regulated. Studies of two yeast genes expressed in the G1 phase of the cell cycle, HO and CLN2, have provided important paradigms for transcriptional regulation. Although the SBF (Swi4/Swi6 box factor) transcription factor activates both genes, the chromatin landscapes that regulate SBF binding are different. Specifically, the CLN2 promoter is constitutively available for SBF binding, whereas HO has a complex two-step promoter in which chromatin changes in one region allow SBF to bind at a downstream location. These studies reveal the role of chromatin in defining the regulatory properties of promoters.<br /> (2013 Elsevier Ltd. All rights reserved)
Details
- Language :
- English
- ISSN :
- 0968-0004
- Volume :
- 38
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Trends in biochemical sciences
- Publication Type :
- Academic Journal
- Accession number :
- 23870664
- Full Text :
- https://doi.org/10.1016/j.tibs.2013.06.009