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Plasma lipid profiling in a large population-based cohort.

Authors :
Weir JM
Wong G
Barlow CK
Greeve MA
Kowalczyk A
Almasy L
Comuzzie AG
Mahaney MC
Jowett JB
Shaw J
Curran JE
Blangero J
Meikle PJ
Source :
Journal of lipid research [J Lipid Res] 2013 Oct; Vol. 54 (10), pp. 2898-908. Date of Electronic Publication: 2013 Jul 18.
Publication Year :
2013

Abstract

We have performed plasma lipid profiling using liquid chromatography electrospray ionization tandem mass spectrometry on a population cohort of more than 1,000 individuals. From 10 μl of plasma we were able to acquire comparative measures of 312 lipids across 23 lipid classes and subclasses including sphingolipids, phospholipids, glycerolipids, and cholesterol esters (CEs) in 20 min. Using linear and logistic regression, we identified statistically significant associations of lipid classes, subclasses, and individual lipid species with anthropometric and physiological measures. In addition to the expected associations of CEs and triacylglycerol with age, sex, and body mass index (BMI), ceramide was significantly higher in males and was independently associated with age and BMI. Associations were also observed for sphingomyelin with age but this lipid subclass was lower in males. Lysophospholipids were associated with age and higher in males, but showed a strong negative association with BMI. Many of these lipids have previously been associated with chronic diseases including cardiovascular disease and may mediate the interactions of age, sex, and obesity with disease risk.

Details

Language :
English
ISSN :
1539-7262
Volume :
54
Issue :
10
Database :
MEDLINE
Journal :
Journal of lipid research
Publication Type :
Academic Journal
Accession number :
23868910
Full Text :
https://doi.org/10.1194/jlr.P035808