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BtpB, a novel Brucella TIR-containing effector protein with immune modulatory functions.
- Source :
-
Frontiers in cellular and infection microbiology [Front Cell Infect Microbiol] 2013 Jul 08; Vol. 3, pp. 28. Date of Electronic Publication: 2013 Jul 08 (Print Publication: 2013). - Publication Year :
- 2013
-
Abstract
- Several bacterial pathogens have TIR domain-containing proteins that contribute to their pathogenesis. We identified a second TIR-containing protein in Brucella spp. that we have designated BtpB. We show it is a potent inhibitor of TLR signaling, probably via MyD88. BtpB is a novel Brucella effector that is translocated into host cells and interferes with activation of dendritic cells. In vivo mouse studies revealed that BtpB is contributing to virulence and control of local inflammatory responses with relevance in the establishment of chronic brucellosis. Together, our results show that BtpB is a novel Brucella effector that plays a major role in the modulation of host innate immune response during infection.
- Subjects :
- Amino Acid Sequence
Animals
Bacterial Proteins immunology
Brucellosis immunology
Brucellosis microbiology
Dendritic Cells immunology
Disease Models, Animal
Female
Mice
Mice, Inbred C57BL
Molecular Sequence Data
Sequence Alignment
Signal Transduction
Survival Analysis
Toll-Like Receptors immunology
Virulence Factors immunology
Bacterial Proteins metabolism
Brucella immunology
Brucella pathogenicity
Immune Evasion
Virulence Factors metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 2235-2988
- Volume :
- 3
- Database :
- MEDLINE
- Journal :
- Frontiers in cellular and infection microbiology
- Publication Type :
- Academic Journal
- Accession number :
- 23847770
- Full Text :
- https://doi.org/10.3389/fcimb.2013.00028