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Time trend of multiple myeloma and associated secondary primary malignancies in Asian patients: a Taiwan population-based study.
- Source :
-
PloS one [PLoS One] 2013 Jul 02; Vol. 8 (7), pp. e68041. Date of Electronic Publication: 2013 Jul 02 (Print Publication: 2013). - Publication Year :
- 2013
-
Abstract
- Studies involving second malignancies in patients with multiple myeloma are limited for the Asian population. Using data from population-based insurance claims, we assessed the risk of developing secondary malignancies after multiple myeloma, in particular hematologic malignancies. A retrospective cohort study was conducted in 3970 patients with newly diagnosed multiple myeloma from the registry of catastrophic illnesses between 1997 and 2009. A total of 15880 subjects without multiple myeloma were randomly selected as comparisons from the insured population, frequency-matched based on gender, age, and the date of diagnosis. The incidence of secondary malignancies was ascertained through cross-referencing with the National Cancer Registry System. The Cox proportional hazards model was used for analyses. The incidence of multiple myeloma in the insured population increased annually. The overall incidence of secondary malignancy was lower in the multiple myeloma cohort than in the comparison cohort (93.6 vs. 104.5 per 10,000 person-years, IRR = 0.90, 95% CI = 0.78-1.04). The incidence of hematologic malignancies was 11-fold greater for multiple myeloma patients (47.2 vs. 4.09 per 10,000 person-years) with an adjusted HR of 13.0 (95% CI = 7.79-21.6) compared with the comparison cohort. The relative risk of secondary malignancy was also strong for myeloid leukemia (21.2 vs. 1.36 per 10,000 person-years). Gender- and age-specific analysis for secondary hematologic malignancies showed that males and patients with multiple myeloma <60 years of age had a higher risk of secondary malignancy than females and patients with multiple myeloma >60 years of age. In conclusion, patients with multiple myeloma, especially younger patients, are at a high risk of hematologic malignancies.
- Subjects :
- Age Factors
Aged
Asian People
Female
Hematologic Neoplasms ethnology
Humans
Incidence
Insurance Claim Review statistics & numerical data
Kaplan-Meier Estimate
Male
Middle Aged
Multiple Myeloma ethnology
Neoplasms, Second Primary ethnology
Proportional Hazards Models
Registries statistics & numerical data
Retrospective Studies
Risk Factors
Taiwan epidemiology
Time Factors
Hematologic Neoplasms diagnosis
Multiple Myeloma diagnosis
Neoplasms, Second Primary diagnosis
Population Surveillance methods
Subjects
Details
- Language :
- English
- ISSN :
- 1932-6203
- Volume :
- 8
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- PloS one
- Publication Type :
- Academic Journal
- Accession number :
- 23844152
- Full Text :
- https://doi.org/10.1371/journal.pone.0068041