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Effectiveness of A(H1N1)pdm09 influenza vaccine in adults recommended for annual influenza vaccination.
- Source :
-
PloS one [PLoS One] 2013 Jun 20; Vol. 8 (6), pp. e66125. Date of Electronic Publication: 2013 Jun 20 (Print Publication: 2013). - Publication Year :
- 2013
-
Abstract
- Introduction: Because of variability in published A(H1N1)pdm09 influenza vaccine effectiveness estimates, we conducted a study in the adults belonging to the risk groups to assess the A(H1N1)pdm09 MF59-adjuvanted influenza vaccine effectiveness.<br />Methods: VE against influenza and/or pneumonia was assessed in the cohort study (n>25000), and vaccine effectiveness against laboratory-confirmed A(H1N1)pdm09 influenza was assessed in a matched case-control study (16 pairs). Odds ratios (OR) and their 95% confidence intervals (95% CI) were calculated by using multivariate logistic regression; vaccine effectiveness was estimated as (1-odds ratio)*100%.<br />Results: Vaccine effectiveness against laboratory-confirmed A(H1N1)pdm09 influenza and influenza and/or pneumonia was 98% (84-100%) and 33% (2-54%) respectively. The vaccine did not prevent influenza and/or pneumonia in 18-59 years old subjects, and was 49% (16-69%) effective in 60 years and older subjects.<br />Conclusions: Even though we cannot entirely rule out that selection bias, residual confounding and/or cross-protection has played a role, the present results indicate that the MF59-adjuvanted A(H1N1)pdm09 influenza vaccine has been effective in preventing laboratory-confirmed A(H1N1)pdm09 influenza and influenza and/or pneumonia, the latter notably in 60 years and older subjects.
- Subjects :
- Adjuvants, Immunologic administration & dosage
Adolescent
Adult
Case-Control Studies
Female
Humans
Influenza Vaccines administration & dosage
Influenza, Human immunology
Influenza, Human virology
Male
Middle Aged
Netherlands
Polysorbates administration & dosage
Retrospective Studies
Squalene administration & dosage
Young Adult
Influenza A Virus, H1N1 Subtype immunology
Influenza Vaccines immunology
Influenza, Human prevention & control
Vaccination
Subjects
Details
- Language :
- English
- ISSN :
- 1932-6203
- Volume :
- 8
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- PloS one
- Publication Type :
- Academic Journal
- Accession number :
- 23840413
- Full Text :
- https://doi.org/10.1371/journal.pone.0066125