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Meningococcal interaction to microvasculature triggers the tissular lesions of purpura fulminans.
- Source :
-
The Journal of infectious diseases [J Infect Dis] 2013 Nov 15; Vol. 208 (10), pp. 1590-7. Date of Electronic Publication: 2013 Jul 09. - Publication Year :
- 2013
-
Abstract
- Neisseria meningitidis is a strict human pathogen that closely interacts with human endothelial cells via type IV pili in vitro. To decipher whether this interaction plays a role in vivo, we set up an experimental model of fulminant meningococcemia in human skin grafted SCID mice using the wild-type strain 2C4.3. Human skin and mouse tissues were sampled 24 hours after bacterial challenge for histopathology, immunohistochemistry and ultrastructural analysis. In all infected mice, N. meningitidis targeted the human vasculature, leading to bacterial and blood thrombi, infectious vasculitis and vascular leakage. Mouse vessels, including brain vessels, remained unaffected by the infectious and thrombotic process, and a nonpiliated Δ pilE derivative of 2C4.3 failed to target human graft vessels and to induce vascular damages. These data demonstrate that N. meningitidis targets human endothelial cells in vivo and that this interaction triggers the vascular damages that characterize purpura fulminans.
- Subjects :
- Animals
Bacterial Adhesion
Endothelial Cells microbiology
Endothelial Cells pathology
Endothelium, Vascular microbiology
Endothelium, Vascular pathology
Female
Fimbriae, Bacterial physiology
Heterografts
Humans
Meningococcal Infections complications
Meningococcal Infections microbiology
Mice
Microvessels pathology
Skin blood supply
Skin pathology
Skin Transplantation
Microvessels microbiology
Neisseria meningitidis physiology
Purpura Fulminans etiology
Purpura Fulminans pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1537-6613
- Volume :
- 208
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- The Journal of infectious diseases
- Publication Type :
- Academic Journal
- Accession number :
- 23840047
- Full Text :
- https://doi.org/10.1093/infdis/jit301