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High expression of M3 muscarinic acetylcholine receptor is a novel biomarker of poor prognostic in patients with non-small cell lung cancer.
- Source :
-
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine [Tumour Biol] 2013 Dec; Vol. 34 (6), pp. 3939-44. Date of Electronic Publication: 2013 Jul 10. - Publication Year :
- 2013
-
Abstract
- We assessed the expression of M3 receptor in non-small cell lung cancer (NSCLC) and determined its relationship with clinicopathological features and its impact on patient outcome. Specimens from 192 patients with NSCLC were investigated by immunohistochemistry for M3 receptor and Ki67 expression. Correlation between the expression of M3 receptor and Ki67 and various clinicopathological features of NSCLC patients was analyzed. We found that M3 receptor expression was gradually elevated from normal to metaplasia/dysplasia tissues to cancer tissues. Furthermore, there was a similar trend for Ki67 expression. Statistical analysis revealed that M3 receptor expression in tumor cells were correlated significantly with stage (P < 0.0001), histology type (P = 0.0003), Ki67 expression (P < 0.0001), tumor size (P < 0.0001), lymph node status (P < 0.0001), LVS invasion (P = 0.0002), and histology grade (P < 0.0001). Patients with M3 receptor high expression showed far lower disease-free survival (DFS) and overall survival (OS) rates than those with M3 receptor low expression. Multivariate Cox regression analysis demonstrated that high M3 receptor expression was an independent prognostic factor for both DFS and OS. High M3 receptor expression correlates with poor survival in NSCLC patients. M3 receptor expression may be related with tumor progression in NSCLC, indicating that M3 receptor may be a novel antineoplastic target in the future.
- Subjects :
- Carcinoma, Non-Small-Cell Lung pathology
Disease-Free Survival
Female
Humans
Immunohistochemistry statistics & numerical data
Ki-67 Antigen biosynthesis
Lung Neoplasms pathology
Male
Middle Aged
Multivariate Analysis
Neoplasm Staging
Prognosis
Proportional Hazards Models
Biomarkers, Tumor biosynthesis
Carcinoma, Non-Small-Cell Lung metabolism
Lung Neoplasms metabolism
Receptor, Muscarinic M3 biosynthesis
Subjects
Details
- Language :
- English
- ISSN :
- 1423-0380
- Volume :
- 34
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 23838802
- Full Text :
- https://doi.org/10.1007/s13277-013-0982-x