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Preliminary assessment of potential toxicity of methylated soybean protein and methylated β-lactoglobulin in male Wistar rats.
- Source :
-
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association [Food Chem Toxicol] 2013 Sep; Vol. 59, pp. 618-25. Date of Electronic Publication: 2013 Jul 05. - Publication Year :
- 2013
-
Abstract
- Methylated soybean protein (MSP) and methylated β-lactoglobulin (MLG), previously confirmed for their antibacterial and antiviral activities, were tested for their potential toxicity in Wistar male Albino rats as one single dose (2500, 5000 and 10,000 mg/kg body wt) or as repeated daily dose (500 and 2500 mg/kg body wt/day) over 28 days to assess potential toxicity. Single acute administration of very high doses (2500, 5000 and 10,000 mg/kg body wt) of MSP and MLG did not produce any mortality. Changes in body weight, organ weight, hematological parameters, histo-pathological images of selected organs, serum albumin, globulin and albumin/globulin ratio, cholesterol, triglycerides and electrolytes were all within normal amounts in the rats fed with these two methylated proteins and not significantly different from controls. The levels of serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), creatinine and urea were slightly reduced by the administration of these two modified proteins indicating the absence of any adverse effect on hepatic or renal functions.<br /> (Copyright © 2013 Elsevier Ltd. All rights reserved.)
- Subjects :
- Animals
Anti-Bacterial Agents administration & dosage
Anti-Bacterial Agents metabolism
Antiviral Agents administration & dosage
Antiviral Agents metabolism
Food Preservatives administration & dosage
Food Preservatives metabolism
Lactoglobulins administration & dosage
Lactoglobulins metabolism
Male
Methylation
No-Observed-Adverse-Effect Level
Plant Proteins, Dietary administration & dosage
Plant Proteins, Dietary metabolism
Rats
Rats, Wistar
Soybean Proteins administration & dosage
Soybean Proteins metabolism
Toxicity Tests, Acute
Toxicity Tests, Subacute
Anti-Bacterial Agents adverse effects
Antiviral Agents adverse effects
Food Preservatives adverse effects
Lactoglobulins adverse effects
Plant Proteins, Dietary adverse effects
Soybean Proteins adverse effects
Subjects
Details
- Language :
- English
- ISSN :
- 1873-6351
- Volume :
- 59
- Database :
- MEDLINE
- Journal :
- Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
- Publication Type :
- Academic Journal
- Accession number :
- 23835286
- Full Text :
- https://doi.org/10.1016/j.fct.2013.06.026