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The bivalent ligand approach as a tool for improving the in vitro anti-Alzheimer multitarget profile of dimebon.
- Source :
-
ChemMedChem [ChemMedChem] 2013 Aug; Vol. 8 (8), pp. 1276-81. Date of Electronic Publication: 2013 Jul 03. - Publication Year :
- 2013
- Subjects :
- Acetylcholinesterase chemistry
Acetylcholinesterase genetics
Acetylcholinesterase metabolism
Alzheimer Disease drug therapy
Amyloid beta-Peptides antagonists & inhibitors
Amyloid beta-Peptides metabolism
Animals
Apoptosis drug effects
Binding Sites
Chickens
Cholinesterase Inhibitors metabolism
Cholinesterase Inhibitors pharmacology
Humans
Indoles pharmacology
Indoles therapeutic use
Molecular Docking Simulation
Neurons cytology
Neurons drug effects
Peptide Fragments antagonists & inhibitors
Peptide Fragments metabolism
Protein Structure, Tertiary
Receptors, N-Methyl-D-Aspartate chemistry
Receptors, N-Methyl-D-Aspartate metabolism
Recombinant Proteins biosynthesis
Recombinant Proteins chemistry
Recombinant Proteins genetics
Cholinesterase Inhibitors chemistry
Indoles chemistry
Ligands
Subjects
Details
- Language :
- English
- ISSN :
- 1860-7187
- Volume :
- 8
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- ChemMedChem
- Publication Type :
- Academic Journal
- Accession number :
- 23824986
- Full Text :
- https://doi.org/10.1002/cmdc.201300263