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Distinct metabolic and vascular effects of dietary triglycerides and cholesterol in atherosclerotic and diabetic mouse models.

Distinct metabolic and vascular effects of dietary triglycerides and cholesterol in atherosclerotic and diabetic mouse models.

Authors :
Laplante MA
Charbonneau A
Avramoglu RK
Pelletier P
Fang X
Bachelard H
Ylä-Herttuala S
Laakso M
Després JP
Deshaies Y
Sweeney G
Mathieu P
Marette A
Source :
American journal of physiology. Endocrinology and metabolism [Am J Physiol Endocrinol Metab] 2013 Sep 01; Vol. 305 (5), pp. E573-84. Date of Electronic Publication: 2013 Jul 02.
Publication Year :
2013

Abstract

Cholesterol and triglyceride-rich Western diets are typically associated with an increased occurrence of type 2 diabetes and vascular diseases. This study aimed to assess the relative impact of dietary cholesterol and triglycerides on glucose tolerance, insulin sensitivity, atherosclerotic plaque formation, and endothelial function. C57BL6 wild-type (C57) mice were compared with atherosclerotic LDLr(-/-) ApoB(100/100) (LRKOB100) and atherosclerotic/diabetic IGF-II × LDLr(-/-) ApoB(100/100) (LRKOB100/IGF) mice. Each group was fed either a standard chow diet, a 0.2% cholesterol diet, a high-fat diet (HFD), or a high-fat 0.2% cholesterol diet for 6 mo. The triglyceride-rich HFD increased body weight, glucose intolerance, and insulin resistance but did not alter endothelial function or atherosclerotic plaque formation. Dietary cholesterol, however, increased plaque formation in LRKOB100 and LRKOB100/IGF animals and decreased endothelial function regardless of genotype. However, cholesterol was not associated with an increase of insulin resistance in LRKOB100 and LRKOB100/IGF mice and, unexpectedly, was even found to reduce the insulin-resistant effect of dietary triglycerides in these animals. Our data indicate that dietary triglycerides and cholesterol have distinct metabolic and vascular effects in obese atherogenic mouse models resulting in dissociation between the impairment of glucose homeostasis and the development of atherosclerosis.

Details

Language :
English
ISSN :
1522-1555
Volume :
305
Issue :
5
Database :
MEDLINE
Journal :
American journal of physiology. Endocrinology and metabolism
Publication Type :
Academic Journal
Accession number :
23820620
Full Text :
https://doi.org/10.1152/ajpendo.00122.2013