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Distinct metabolic and vascular effects of dietary triglycerides and cholesterol in atherosclerotic and diabetic mouse models.
Distinct metabolic and vascular effects of dietary triglycerides and cholesterol in atherosclerotic and diabetic mouse models.
- Source :
-
American journal of physiology. Endocrinology and metabolism [Am J Physiol Endocrinol Metab] 2013 Sep 01; Vol. 305 (5), pp. E573-84. Date of Electronic Publication: 2013 Jul 02. - Publication Year :
- 2013
-
Abstract
- Cholesterol and triglyceride-rich Western diets are typically associated with an increased occurrence of type 2 diabetes and vascular diseases. This study aimed to assess the relative impact of dietary cholesterol and triglycerides on glucose tolerance, insulin sensitivity, atherosclerotic plaque formation, and endothelial function. C57BL6 wild-type (C57) mice were compared with atherosclerotic LDLr(-/-) ApoB(100/100) (LRKOB100) and atherosclerotic/diabetic IGF-II × LDLr(-/-) ApoB(100/100) (LRKOB100/IGF) mice. Each group was fed either a standard chow diet, a 0.2% cholesterol diet, a high-fat diet (HFD), or a high-fat 0.2% cholesterol diet for 6 mo. The triglyceride-rich HFD increased body weight, glucose intolerance, and insulin resistance but did not alter endothelial function or atherosclerotic plaque formation. Dietary cholesterol, however, increased plaque formation in LRKOB100 and LRKOB100/IGF animals and decreased endothelial function regardless of genotype. However, cholesterol was not associated with an increase of insulin resistance in LRKOB100 and LRKOB100/IGF mice and, unexpectedly, was even found to reduce the insulin-resistant effect of dietary triglycerides in these animals. Our data indicate that dietary triglycerides and cholesterol have distinct metabolic and vascular effects in obese atherogenic mouse models resulting in dissociation between the impairment of glucose homeostasis and the development of atherosclerosis.
- Subjects :
- Animals
Cholesterol, Dietary metabolism
Diabetes Mellitus, Type 2 metabolism
Disease Models, Animal
Glucose Clamp Technique
Glucose Tolerance Test
Histocytochemistry
Insulin Resistance
Male
Mice
Mice, Inbred C57BL
Mice, Knockout
Muscle Contraction physiology
Specific Pathogen-Free Organisms
Triglycerides metabolism
Atherosclerosis metabolism
Cholesterol, Dietary administration & dosage
Diabetes Mellitus, Experimental metabolism
Triglycerides administration & dosage
Subjects
Details
- Language :
- English
- ISSN :
- 1522-1555
- Volume :
- 305
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- American journal of physiology. Endocrinology and metabolism
- Publication Type :
- Academic Journal
- Accession number :
- 23820620
- Full Text :
- https://doi.org/10.1152/ajpendo.00122.2013