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Synthesis of 1,4-anthracene-9,10-dione derivatives and their regulation of nitric oxide, IL-1β and TNF-α in activated RAW264.7 cells.
- Source :
-
Chemical biology & drug design [Chem Biol Drug Des] 2013 Oct; Vol. 82 (4), pp. 463-7. Date of Electronic Publication: 2013 Aug 10. - Publication Year :
- 2013
-
Abstract
- Mitoxantrone is an anthracenedione antineoplastic and immunosuppressive agent approved for multiple sclerosis treatment. Novel mono- and disubstituted anthraquinone derivatives, analogues of mitoxantrone, were synthesized through the addition of lipophilic amino alcohols and evaluated for their effect on IL-1β, TNF-α and nitric oxide production by LPS/IFN-γ-stimulated RAW264.7 cells. The disubstituted 1,4-anthracene-9,10-dione 10 showed significant inhibition of nitric oxide, TNF-α and IL-1β production at the concentration of 5 μg/mL, with a much lower cytotoxicity than mitoxantrone. The monosubstituted 3, 4, 11, 12 and 13 also displayed a moderate to good inhibitory capacity on IL-1β production. However, the methylated compounds 11, 12 and 13 failed to inhibit the TNF-α production, and compound 13 was the only one to decrease the production of nitric oxide. None of these derivatives was toxic at the tested concentrations. Compounds 10 and 13 had better inhibitory capacity of the inflammatory mediators analyzed, with reliable viability of the cells.<br /> (© 2013 John Wiley & Sons A/S.)
Details
- Language :
- English
- ISSN :
- 1747-0285
- Volume :
- 82
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Chemical biology & drug design
- Publication Type :
- Report
- Accession number :
- 23819539
- Full Text :
- https://doi.org/10.1111/cbdd.12183