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[Bone structure in rheumatoid arthritis].
- Source :
-
Clinical calcium [Clin Calcium] 2013 Jul; Vol. 23 (7), pp. 983-91. - Publication Year :
- 2013
-
Abstract
- In rheumatoid arthritis (RA) , the osteoclast pathway is activated by abnormal immune conditions accompanied by chronic inflammation, resulting in periarticular osteoporosis and local bone destruction around joints. In addition, multiple factors, including reduced physical activity and pharmacotherapies such as steroids, lead to systemic osteoporosis. These conditions cause decreasing bone mineral density and deterioration of bone quality, and expose patients to increased risk of fracture. Understanding the bone structures of RA and evaluating fracture risk are central to the treatment of RA.
- Subjects :
- Arthritis, Rheumatoid metabolism
Bone Density drug effects
Bone Density physiology
Bone and Bones metabolism
Humans
Joints metabolism
Osteoclasts metabolism
Osteoclasts pathology
Osteoporosis metabolism
Osteoporosis pathology
Arthritis, Rheumatoid pathology
Bone and Bones pathology
Joints pathology
Subjects
Details
- Language :
- Japanese
- ISSN :
- 0917-5857
- Volume :
- 23
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Clinical calcium
- Publication Type :
- Academic Journal
- Accession number :
- 23811586
- Full Text :
- https://doi.org/CliCa1307983991