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Lipid signaling cascades of orexin/hypocretin receptors.
- Source :
-
Biochimie [Biochimie] 2014 Jan; Vol. 96, pp. 158-65. Date of Electronic Publication: 2013 Jun 28. - Publication Year :
- 2014
-
Abstract
- Orexins - orexin-A and orexin-B - are neuropeptides with significant role in regulation of fundamental physiological processes such as sleep-wakefulness cycle. Orexins act via G-protein-coupled OX1 and OX2 receptors, which are found, in addition to the central nervous system, also in a number of peripheral organs. Orexin receptors show high degree of signaling promiscuity. One particularly prominent way of signaling for these receptors is via phospholipase cascades, including the phospholipase C, phospholipase D and phospholipase A2 cascades, and also diacylglycerol lipase and phosphoinositide-3-kinase pathways. Most analyses have been performed in recombinant cells; there are indications of some of these cascades in native cells while the significance of other cascades remains to be shown. In this review, I present these pathways, their activation mechanisms and their physiological significance.<br /> (Copyright © 2013 Elsevier Masson SAS. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 1638-6183
- Volume :
- 96
- Database :
- MEDLINE
- Journal :
- Biochimie
- Publication Type :
- Academic Journal
- Accession number :
- 23810911
- Full Text :
- https://doi.org/10.1016/j.biochi.2013.06.015