Start Over

Breast cancer and venous disease: a retrospective cohort study.

Authors :: Serra R
Buffone G
Miglietta AM
Abonante S
Giordano V
Renne M
Lugarà M
de Franciscis S
Source :: Annals of vascular surgery [Ann Vasc Surg] 2013 Aug; Vol. 27 (6), pp. 762-6. Date of Electronic Publication: 2013 Jul 01.
Publication Year :: 2013
Abstract: Background: Breast cancer (BC) and chronic venous disease (CVD) are in some way related to hormonal effects, and often the clinical manifestations of CVD intersect with the clinical course of BC. This article describes the correlations between these clinical conditions.<br />Methods: A total of 1138 female patients with BC were retrospectively reviewed in a 5-year period to obtain clinical information about the frequency and characteristics of contemporary CVD and the relative correlations with estrogen and progesterone receptor status.<br />Results: The presence of BC was associated with concomitant CVD clinical manifestations in patients with positive estrogen receptor status, whereas no association was found in patients with negative estrogen receptor status. The presence of negative estrogen receptor status associated with positive progesterone receptor status seemed to be even protective against CVD. Patients with more severe manifestations of CVD had positive estrogen receptor status.<br />Conclusions: BC and CVD seem to be strongly associated. Positive estrogen receptor status may predispose to a more severe clinical course of venous disease when it occurs in patients with BC.<br /> (Copyright © 2013 Elsevier Inc. All rights reserved.)