Back to Search
Start Over
Different immunohistochemical levels of Hsp60 and Hsp70 in a subset of brain tumors and putative role of Hsp60 in neuroepithelial tumorigenesis.
- Source :
-
European journal of histochemistry : EJH [Eur J Histochem] 2013 Jun 28; Vol. 57 (2), pp. e20. Date of Electronic Publication: 2013 Jun 28. - Publication Year :
- 2013
-
Abstract
- In this work we analysed, by immunohistochemistry, a series of brain tumors to detect the levels and cellular distribution of Hsp60 and Hsp70. We found that Hsp60 levels were significantly higher than those of Hsp70 in neuroepithelial tumors, while levels of both molecules were not significantly different from each other in meningeal neoplasms. In particular, Hsp60 immunopositivity was present mainly at the cytoplasmic level, while Hsp70 immunopositivity was found both in the cytoplasm and in the nucleus of tumor cells. The levels of these molecules in healthy control cells were always very low. Finally, Hsp60 and Hsp70 levels did not correlate with the different types (WHO grade) of neoplasm. Our results are partially in agreement with previous studies and suggest that Hsp60 is not increased by a passive phenomenon (e.g., due to the stress caused by the peritumor environment on cancer cells) but may be actively implicated in tumor progression, e.g. inhibiting tumor cell death or antitumor immune system response, as already postulated in vitro. We also briefly discuss the most recent publications on the extramitochondrial localization of Hsp60 in tumor cells and its role in tumor progression.
- Subjects :
- Adolescent
Adult
Aged
Aged, 80 and over
Chaperonin 60 genetics
Child
Child, Preschool
Female
HSP70 Heat-Shock Proteins genetics
Humans
Immunohistochemistry
Male
Middle Aged
Brain Neoplasms physiopathology
Chaperonin 60 metabolism
HSP70 Heat-Shock Proteins metabolism
Meningeal Neoplasms physiopathology
Neoplasms, Neuroepithelial physiopathology
Neuroepithelial Cells pathology
Subjects
Details
- Language :
- English
- ISSN :
- 2038-8306
- Volume :
- 57
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- European journal of histochemistry : EJH
- Publication Type :
- Academic Journal
- Accession number :
- 23807299
- Full Text :
- https://doi.org/10.4081/ejh.2013.e20