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Alstoniaphyllines A-C, unusual nitrogenous derivatives from the bark of Alstonia macrophylla.
- Source :
-
Journal of natural products [J Nat Prod] 2013 Apr 26; Vol. 76 (4), pp. 723-6. Date of Electronic Publication: 2013 Apr 08. - Publication Year :
- 2013
-
Abstract
- Chemical investigation of an alkaloidal extract of Alstonia macrophylla bark led to the isolation and identification of two new nitrogenous derivatives, alstoniaphyllines A (1) and B (2), a new indole alkaloid, alstoniaphylline C (4), and eight known alkaloids (3, 5-11). Alstonisine (9) exhibited antiplasmodial activity against Plasmodium falciparum, with an IC50 of 7.6 μM.
- Subjects :
- Alkaloids chemistry
Alkaloids pharmacology
Antimalarials chemistry
Antimalarials pharmacology
Drug Screening Assays, Antitumor
Humans
Indole Alkaloids chemistry
Indole Alkaloids pharmacology
Indoles
Inhibitory Concentration 50
KB Cells
Microbial Sensitivity Tests
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Oxindoles
Plant Bark chemistry
Plasmodium falciparum drug effects
Spiro Compounds
Thailand
Alkaloids isolation & purification
Alstonia chemistry
Antimalarials isolation & purification
Indole Alkaloids isolation & purification
Subjects
Details
- Language :
- English
- ISSN :
- 1520-6025
- Volume :
- 76
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Journal of natural products
- Publication Type :
- Academic Journal
- Accession number :
- 23806072
- Full Text :
- https://doi.org/10.1021/np3006937