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Prevention versus intervention of type 1 diabetes.
- Source :
-
Clinical immunology (Orlando, Fla.) [Clin Immunol] 2013 Dec; Vol. 149 (3), pp. 332-8. Date of Electronic Publication: 2013 Jun 10. - Publication Year :
- 2013
-
Abstract
- Type 1 diabetes (T1D) is a cell-mediated autoimmune disease. New cases of T1D are on the increase and exogenous insulin therapy is the only intervention regularly initiated for T1D patients. Though tremendous strides have been made in prediction of T1D, prevention and intervention strategies have not experienced the same success. In this review, we will discuss some possible reasons why new intervention therapies for T1D have not been implemented into the mainstream treatment regimen for T1D patients. We will also discuss potential caveats for why prevention and intervention trials in T1D may not have experienced the same success as prediction trials.<br /> (Copyright © 2013 Elsevier Inc. All rights reserved.)
- Subjects :
- Abatacept
Antibodies, Monoclonal, Humanized therapeutic use
Autoimmunity
CD3 Complex therapeutic use
Clinical Trials as Topic
Diabetes Mellitus, Type 1 immunology
Etanercept
Glutamate Decarboxylase therapeutic use
Humans
Immunoconjugates therapeutic use
Immunoglobulin G therapeutic use
Insulin metabolism
Insulin-Secreting Cells drug effects
Insulin-Secreting Cells immunology
Insulin-Secreting Cells pathology
Receptors, Tumor Necrosis Factor therapeutic use
Diabetes Mellitus, Type 1 drug therapy
Diabetes Mellitus, Type 1 prevention & control
Hypoglycemic Agents therapeutic use
Insulin therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 1521-7035
- Volume :
- 149
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Clinical immunology (Orlando, Fla.)
- Publication Type :
- Academic Journal
- Accession number :
- 23803322
- Full Text :
- https://doi.org/10.1016/j.clim.2013.05.018