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Incidental focal colorectal ¹⁸F-fluorodeoxyglucose uptake on positron emission tomography/computed tomography.
- Source :
-
World journal of gastroenterology [World J Gastroenterol] 2013 Jun 14; Vol. 19 (22), pp. 3453-8. - Publication Year :
- 2013
-
Abstract
- Aim: To assess the clinical significance of incidental focal colorectal ¹⁸F-fluorodeoxyglucose (¹⁸F-FDG) uptake on ¹⁸F-FDG-positron emission tomography/computed tomography (PET/CT).<br />Methods: The records of all the cases which had undergone colonoscopy after PET/CT within a two weeks interval were reviewed. Adenomas were considered advanced when they were villous, ≥ 10 mm in size, or had high-grade dysplasia. Colorectal cancers and advanced adenomas are collectively referred to as advanced colorectal neoplasms. Receiver-operating characteristic curve analysis was used to determine the significant predictive maximum standardized uptake value (SUVmax) cutoff value for advanced colorectal neoplasms and cancer.<br />Results: Ninety-five colorectal lesions matched the site of incidental focal colorectal ¹⁸F-FDG uptake on PET/CT and 146 did not. Colonoscopy showed advanced colorectal neoplasms corresponding to the site of ¹⁸F-FDG uptake in 49 of the 95 (51.5%) lesions with incidental uptake. Of the lesions without incidental uptake, only 6 of 146 (4.1%) had advanced colorectal neoplasms on colonoscopy, indicating a statistically significant difference between the two groups (P < 0.001). The sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy of incidental focal ¹⁸F-FDG uptake in identifying advanced colorectal neoplasms were 89.1%, 75.3%, 51.6%, 95.9%, and 78.4%, respectively. In detecting only CRC, these values were 89.2%, 69.6%, 34.7%, 97.3%, and 72.6%, respectively. The significant SUVmax cutoff value for advanced colorectal neoplasms (area under the curve 0.755, P < 0.001) was 4.35, with a sensitivity, specificity, PPV, NPV, and accuracy of 75.5%, 65.2%, 69.8%, 71.4% and 70.5%, respectively. For CRC, 5.05 was the significant SUVmax cutoff value (area under the curve 0.817, P < 0.001), with a sensitivity, specificity, PPV, NPV, and accuracy of 84.8%, 71.0%, 80.9%, 89.8%, and 75.8%, respectively.<br />Conclusion: The presence of incidental focal colorectal ¹⁸F-FDG uptake on PET/CT with a SUVmax ≥ 4.35 increases the likelihood of an advanced colorectal neoplasm.
- Subjects :
- Adenoma metabolism
Adenoma pathology
Adult
Aged
Aged, 80 and over
Area Under Curve
Carcinoma metabolism
Carcinoma pathology
Colonoscopy
Colorectal Neoplasms metabolism
Colorectal Neoplasms pathology
Female
Humans
Male
Middle Aged
Predictive Value of Tests
Prognosis
ROC Curve
Adenoma diagnostic imaging
Carcinoma diagnostic imaging
Colorectal Neoplasms diagnostic imaging
Fluorodeoxyglucose F18 pharmacokinetics
Multimodal Imaging methods
Positron-Emission Tomography
Radiopharmaceuticals pharmacokinetics
Tomography, X-Ray Computed
Subjects
Details
- Language :
- English
- ISSN :
- 2219-2840
- Volume :
- 19
- Issue :
- 22
- Database :
- MEDLINE
- Journal :
- World journal of gastroenterology
- Publication Type :
- Academic Journal
- Accession number :
- 23801838
- Full Text :
- https://doi.org/10.3748/wjg.v19.i22.3453