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Movement disorders in GLUT1 deficiency syndrome respond to the modified Atkins diet.
- Source :
-
Movement disorders : official journal of the Movement Disorder Society [Mov Disord] 2013 Sep; Vol. 28 (10), pp. 1439-42. Date of Electronic Publication: 2013 Jun 25. - Publication Year :
- 2013
-
Abstract
- Background: Movement disorders are a prominent feature of glucose transporter-1 (GLUT1) deficiency syndrome (GLUT1DS). First-choice treatment is a ketogenic diet, but compliance is poor. We have investigated the effect of the modified Atkins diet as an alternative treatment for movement disorders in GLUT1DS.<br />Methods: Four patients with GLUT1DS ages 15 to 30 years who had movement disorders as the most prominent feature were prospectively evaluated after initiation of the modified Atkins diet. Movement disorders included dystonia, ataxia, myoclonus, and spasticity, either continuous or paroxysmal, triggered by action or exercise. Duration of treatment ranged from 3 months to 16 months.<br />Results: All patients reached mild to moderate ketosis and experienced remarkable improvement in the frequency and severity of paroxysmal movement disorders. Cognitive function also improved subjectively.<br />Conclusions: The modified Atkins diet is an effective and feasible alternative to the ketogenic diet for the treatment of GLUT1DS-related paroxysmal movement disorders in adolescence and adulthood.<br /> (© 2013 International Parkinson and Movement Disorder Society.)
- Subjects :
- Adolescent
Adult
Ataxia diet therapy
Ataxia etiology
Carbohydrate Metabolism, Inborn Errors genetics
Cognition Disorders diet therapy
Cognition Disorders etiology
Cognition Disorders psychology
Female
Humans
Ketosis diet therapy
Ketosis etiology
Male
Monosaccharide Transport Proteins genetics
Movement Disorders genetics
Myoclonus diet therapy
Myoclonus etiology
Patient Compliance
Seizures etiology
Treatment Outcome
Young Adult
Carbohydrate Metabolism, Inborn Errors diet therapy
Diet, Carbohydrate-Restricted adverse effects
Monosaccharide Transport Proteins deficiency
Movement Disorders diet therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1531-8257
- Volume :
- 28
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Movement disorders : official journal of the Movement Disorder Society
- Publication Type :
- Academic Journal
- Accession number :
- 23801573
- Full Text :
- https://doi.org/10.1002/mds.25515