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Mediastinal epithelioid hemangioendothelioma with abundant spindle cells and osteoclast-like giant cells mimicking malignant fibrous histiocytoma.
- Source :
-
Diagnostic pathology [Diagn Pathol] 2013 Jun 21; Vol. 8, pp. 103. Date of Electronic Publication: 2013 Jun 21. - Publication Year :
- 2013
-
Abstract
- Epithelioid hemangioendothelioma is a relatively uncommon lesion usually presenting in soft tissues. The occurrence in the mediastinum is exceptional rare. Histologically, this tumor is characterized by epithelioid cells with intracytoplasmic vacuoles in a hyalinized or mucinous stroma. Occasionally, spindle cells or osteoclast-like giant cells can be observed. Herein, we present a case of epithelioid hemangioendothelioma in a 38 year-old Chinese male. The tumor was predominantly composed of abundant spindle cells with marked atypia and scattered osteoclast-like giant cells reminiscent of malignant fibrous histiocytoma. The unusual histological appearance can pose a great diagnostic challenge. It may be easily misdiagnosed, especially if the specimen is limited or from fine-needle aspiration.
- Subjects :
- Adult
Biomarkers, Tumor analysis
Biopsy, Fine-Needle
Chemotherapy, Adjuvant
Diagnosis, Differential
Giant Cells chemistry
Hemangioendothelioma, Epithelioid chemistry
Hemangioendothelioma, Epithelioid therapy
Humans
Immunohistochemistry
Male
Mediastinal Neoplasms chemistry
Mediastinal Neoplasms therapy
Osteoclasts chemistry
Predictive Value of Tests
Tomography, X-Ray Computed
Treatment Outcome
Giant Cells pathology
Hemangioendothelioma, Epithelioid pathology
Histiocytoma, Malignant Fibrous pathology
Mediastinal Neoplasms pathology
Osteoclasts pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1746-1596
- Volume :
- 8
- Database :
- MEDLINE
- Journal :
- Diagnostic pathology
- Publication Type :
- Academic Journal
- Accession number :
- 23800015
- Full Text :
- https://doi.org/10.1186/1746-1596-8-103