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Dearomatization strategy of β-enamino ester: construction of indenoazepines via tandem Michael addition/polycyclization.
- Source :
-
Organic letters [Org Lett] 2013 Jul 05; Vol. 15 (13), pp. 3464-7. Date of Electronic Publication: 2013 Jun 24. - Publication Year :
- 2013
-
Abstract
- A dearomatization strategy of β-enamino esters was developed to construct indenoazepine derivatives. The oxidative dearomatization was combined with a base-promoted tandem Michael addition/polycyclization and an acid-catalyzed aromatization. The nonaromatic structure of the Michael adducts might be essential to the realization of the 7-endo-dig cyclization.
Details
- Language :
- English
- ISSN :
- 1523-7052
- Volume :
- 15
- Issue :
- 13
- Database :
- MEDLINE
- Journal :
- Organic letters
- Publication Type :
- Academic Journal
- Accession number :
- 23795890
- Full Text :
- https://doi.org/10.1021/ol401553n