Propargyl amides as irreversible inhibitors of cysteine proteases--a lesson on the biological reactivity of alkynes.

Authors :: Arkona C
Rademann J
Source :: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2013 Aug 05; Vol. 52 (32), pp. 8210-2. Date of Electronic Publication: 2013 Jun 21.
Publication Year :: 2013

Subjects :: Humans
Alkynes chemistry
Alkynes pharmacology
Amides chemistry
Cysteine Proteases chemistry
Cysteine Proteases metabolism
Pargyline analogs & derivatives
Pargyline pharmacology
Protease Inhibitors chemistry
Protease Inhibitors pharmacology

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