Adverse drug reactions induced by valproic acid.

Authors :: Nanau RM
Neuman MG
Source :: Clinical biochemistry [Clin Biochem] 2013 Oct; Vol. 46 (15), pp. 1323-38. Date of Electronic Publication: 2013 Jun 20.
Publication Year :: 2013
Abstract: Valproic acid is a widely-used first-generation antiepileptic drug, prescribed predominantly in epilepsy and psychiatric disorders. VPA has good efficacy and pharmacoeconomic profiles, as well as a relatively favorable safety profile. However, adverse drug reactions have been reported in relation with valproic acid use, either as monotherapy or polytherapy with other antiepileptic drugs or antipsychotic drugs. This systematic review discusses valproic acid adverse drug reactions, in terms of hepatotoxicity, mitochondrial toxicity, hyperammonemic encephalopathy, hypersensitivity syndrome reactions, neurological toxicity, metabolic and endocrine adverse events, and teratogenicity.<br /> (Copyright © 2013 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.)