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Low tube voltage intermediate tube current liver MDCT: sinogram-affirmed iterative reconstruction algorithm for detection of hypervascular hepatocellular carcinoma.
- Source :
-
AJR. American journal of roentgenology [AJR Am J Roentgenol] 2013 Jul; Vol. 201 (1), pp. 23-32. - Publication Year :
- 2013
-
Abstract
- Objective: The purpose of this study was to compare image quality and lesion detectability in the evaluation of hypervascular hepatocellular carcinoma (HCC) on low-tube-voltage half-dose liver CT scans subjected to sinogram-affirmed iterative reconstruction (SAFIRE) with the quality and detectability on full-dose scans reconstructed with filtered back projection (FBP).<br />Materials and Methods: A total of 126 patients with suspected HCC who underwent liver CT including arterial phase scanning at 80 kVp in the dual-source mode (300 mAs for each tube) were included in the study. The half-dose arterial scans were reconstructed with FBP, iterative reconstruction in image space (IRIS), and five SAFIRE strengths (S1-S5) and were compared with full-dose virtual scans (600 mA) reconstructed with FBP. We assessed image noise, contrast-to-noise ratio (CNR) of the liver and blood vessels, and lesionto-liver CNR. Two radiologists evaluated image quality and lesion detectability attained with the different imaging sets.<br />Results: Image noise on SAFIRE images was significantly lower than that on the other images, and the CNRs on SAFIRE images were higher than those on half-dose FBP images (p < 0.001). In addition, lesion-to-liver CNR on the half-dose S5 SAFIRE images was higher than on IRIS and full-dose FBP images (p < 0.05). Among the half-dose scans, SAFIRE images had significantly better image quality than FBP images (p < 0.05). Regarding lesion detection, half-dose SAFIRE images were better than half-dose FBP images and were comparable with full-dose FBP images (observer 1, 91.8% vs 96%; observer 2, 98% vs 98%; p > 0.05).<br />Conclusion: Performing half-dose 80-kVp liver CT with SAFIRE technique may increase image quality and afford comparable lesion detectability of hypervascular HCC at a reduced radiation dose compared with full-dose CT with FBP.
- Subjects :
- Adult
Aged
Aged, 80 and over
Analysis of Variance
Contrast Media
Diagnosis, Differential
Female
Humans
Iohexol analogs & derivatives
Male
Middle Aged
Radiation Dosage
Signal-To-Noise Ratio
Statistics, Nonparametric
Algorithms
Carcinoma, Hepatocellular diagnostic imaging
Liver Neoplasms diagnostic imaging
Radiographic Image Interpretation, Computer-Assisted methods
Tomography, X-Ray Computed methods
Subjects
Details
- Language :
- English
- ISSN :
- 1546-3141
- Volume :
- 201
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- AJR. American journal of roentgenology
- Publication Type :
- Academic Journal
- Accession number :
- 23789655
- Full Text :
- https://doi.org/10.2214/AJR.12.10000