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Effect of Zishenshengxue capsule on myelosuppression in mice induced by cyclophosphamide.
- Source :
-
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan [J Tradit Chin Med] 2013 Apr; Vol. 33 (2), pp. 233-7. - Publication Year :
- 2013
-
Abstract
- Objective: To explore the inhibitory effect of Zishenshengxue capsule (ZSC) on myelosuppression in mice induced by cyclophosphamide.<br />Methods: Kunming mice were randomly assigned into a control group, myelosuppression group, or groups for mice with myelosuppression receiving high dose ZSC, middle dose ZSC, low dose ZSC or Yixuesheng. Myelosuppression was induced by peritoneal injection of cyclophosphamide. ZSC and cyclophosphamide were administered simultaneously. The numbers of peripheral blood cells and bone marrow karyocytes were counted. Cell proliferation activity and colony formation of granulocyte-monocyte series hemopoietic progenitor cells (C-GMs) and cell cycle were detected.<br />Results: The numbers of white blood cells in the middle and high dose ZSC groups were significantly increased at the 12th and 13th day (P < 0.01) and 0.01) compared with the myelosuppression group. C-GMs of middle and high dose ZSC groups significantly increased (P < 0.01). The percentage of G1 phase in the high dose ZSC group decreased (P < 0.01) and the percentage of S and G2 phase increased (P < 0.01).<br />Conclusion: ZSC increased the numbers of peripheral white blood cells, bone marrow karyocytes and C-GMs. ZSC also increased cell proliferation activity and removed the G1 phase block. Thus, ZSC could reduce myelosuppression in mice induced by cyclophosphamide.
- Subjects :
- Anemia, Aplastic physiopathology
Animals
Bone Marrow Cells cytology
Bone Marrow Cells drug effects
Capsules administration & dosage
Cell Cycle drug effects
Humans
Leukocyte Count
Leukocytes cytology
Leukocytes drug effects
Male
Mice
Anemia, Aplastic drug therapy
Bone Marrow drug effects
Cyclophosphamide adverse effects
Drugs, Chinese Herbal administration & dosage
Subjects
Details
- Language :
- English
- ISSN :
- 0255-2922
- Volume :
- 33
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan
- Publication Type :
- Academic Journal
- Accession number :
- 23789223
- Full Text :
- https://doi.org/10.1016/s0254-6272(13)60131-4