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Long-term functional and survival outcomes after induction chemotherapy and risk-based definitive therapy for locally advanced squamous cell carcinoma of the head and neck.
- Source :
-
Head & neck [Head Neck] 2014 Apr; Vol. 36 (4), pp. 474-80. Date of Electronic Publication: 2013 Jun 18. - Publication Year :
- 2014
-
Abstract
- Background: The purpose of this study was to evaluate long-term outcomes after induction chemotherapy followed by "risk-based" local therapy for locally-advanced squamous cell carcinoma of the head and neck (SCCHN).<br />Methods: Forty-seven patients (stage IV; ≥N2b) were enrolled in a phase II trial. Baseline and 24-month functional measures included modified barium swallow (MBS) studies, oropharyngeal swallow efficiency (OPSE), and the MD Anderson Dysphagia Inventory (MDADI). Functional status was assessed at 5 years.<br />Results: Five-year overall survival (OS) was 89% (95% confidence interval [CI], 81% to 99%). A nonsignificant 13% average reduction in swallowing efficiency (OPSE) was observed at 24 months relative to baseline (p = .191). MDADI scores approximated baseline at 24 months. Among 42 long-term survivors (median, 5.9 years), 3 patients (7.1%) had chronic dysphagia. The rate of final gastrostomy dependence was 4.8% (2 of 42).<br />Conclusion: Sequential chemoradiotherapy achieved favorable outcomes among patients with locally advanced SCCHN, mainly of oropharyngeal origin. MBS and MDADI scores found modest swallowing deterioration at 2 years, and chronic aspiration was uncommon in long-term survivors.<br /> (Copyright © 2013 Wiley Periodicals, Inc.)
- Subjects :
- Antibodies, Monoclonal, Humanized administration & dosage
Antineoplastic Combined Chemotherapy Protocols therapeutic use
Carboplatin administration & dosage
Carcinoma, Squamous Cell pathology
Cetuximab
Female
Head and Neck Neoplasms pathology
Humans
Male
Middle Aged
Paclitaxel administration & dosage
Radiotherapy, Adjuvant
Carcinoma, Squamous Cell mortality
Carcinoma, Squamous Cell therapy
Deglutition Disorders etiology
Gastrostomy statistics & numerical data
Head and Neck Neoplasms mortality
Head and Neck Neoplasms therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1097-0347
- Volume :
- 36
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Head & neck
- Publication Type :
- Academic Journal
- Accession number :
- 23780650
- Full Text :
- https://doi.org/10.1002/hed.23330