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Genomic regions affecting backfat thickness and cannon bone circumference identified by genome-wide association study in a Duroc pig population.
- Source :
-
Animal genetics [Anim Genet] 2013 Aug; Vol. 44 (4), pp. 454-7. Date of Electronic Publication: 2012 Dec 12. - Publication Year :
- 2013
-
Abstract
- We performed a genome-wide association study using the porcine 60K SNP array to detect QTL regions for nine traits in a three-generational Duroc samples (n = 651), viz. generations 1, 2 and 3 from a population selected over five generations using a closed nucleus breeding scheme. We applied a linear mixed model for association mapping to detect SNP effects, adjusting for fixed effects (sex and season) and random polygenic effects (reflecting genetic relatedness), and derived a likelihood ratio statistic for each SNP using the efficient mixed-model association method. We detected a region on SSC6 for backfat thickness (BFT) and on SSC7 for cannon bone circumference (CANNON), with a genome-wide significance of P < 0.01 after Bonferroni correction. These regions had been detected previously in other pig populations. Six genes are located in the BFT-associated region, while the CANNON-associated region includes 66 genes. In the future, significantly associated SNPs, derived by sequencing the coding regions of the six genes in the BFT region, can be used in marker-assisted selection of BFT, whereas haplotypes constructed from the SSC7 region with strong LD can be used to select for the CANNON trait in our resource family.<br /> (© 2012 The Authors, Animal Genetics © 2012 Stichting International Foundation for Animal Genetics.)
- Subjects :
- Adipose Tissue growth & development
Animals
Breeding
Chromosome Mapping veterinary
Gene Expression Profiling veterinary
Genetic Markers
Haplotypes
Leg Bones growth & development
Linear Models
Oligonucleotide Array Sequence Analysis veterinary
Phenotype
Sequence Analysis, DNA veterinary
Swine growth & development
Swine metabolism
Genome genetics
Genome-Wide Association Study veterinary
Polymorphism, Single Nucleotide genetics
Quantitative Trait Loci genetics
Swine genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1365-2052
- Volume :
- 44
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Animal genetics
- Publication Type :
- Academic Journal
- Accession number :
- 23777416
- Full Text :
- https://doi.org/10.1111/age.12018