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FOXA1 expression after neoadjuvant chemotherapy is a prognostic marker in estrogen receptor-positive breast cancer.
- Source :
-
Breast cancer (Tokyo, Japan) [Breast Cancer] 2015 May; Vol. 22 (3), pp. 308-16. Date of Electronic Publication: 2013 Jun 16. - Publication Year :
- 2015
-
Abstract
- Background: Recent studies have indicated that the response to chemotherapy and the prognostic impact of a pathological complete response (pCR) after neoadjuvant chemotherapy differ among breast cancer subtypes. Predictors of response to chemotherapy and prognostic factors for survival might be different in estrogen receptor (ER)-positive breast cancer.<br />Methods: Women with Stage II to III ER-positive HER2-negative breast cancer treated with anthracycline and taxane-containing neoadjuvant chemotherapy between 2003 and 2011 were retrospectively analyzed. Expression of forkhead box A1 (FOXA1), B cell lymphoma 2 (BCL2) and microtubule-associated protein tau (MAPT) as well as ER, progesterone receptor, HER2 and Ki67 was examined by immunohistochemistry in pre- and post-treatment specimens. Factors predictive of response to neoadjuvant chemotherapy and distant disease-free survival were analyzed.<br />Results: Tumor grade was positively correlated with Ki67 expression. Expression levels of ER were positively correlated with expression levels of HER2, BCL2, FOXA1 and MAPT in pre-treatment tumors. The Ki67 labeling index was the only factor that was significantly associated with clinical response measured by the reduction of tumor volume and pCR. Lymph node status, expression of ER before neoadjuvant chemotherapy and expression of FOXA1 after neoadjuvant chemotherapy were significantly associated with distant disease-free survival, both by univariate and multivariate analyses.<br />Conclusions: Patients with ER-positive HER2-negative breast cancer should be selected for neoadjuvant chemotherapy. FOXA1 expression could be a prognostic marker in ER-positive breast cancer.
- Subjects :
- Adult
Aged
Breast Neoplasms drug therapy
Breast Neoplasms mortality
Breast Neoplasms pathology
Female
Follow-Up Studies
Humans
Immunoenzyme Techniques
Middle Aged
Neoplasm Grading
Neoplasm Invasiveness
Neoplasm Recurrence, Local drug therapy
Neoplasm Recurrence, Local mortality
Neoplasm Recurrence, Local pathology
Neoplasm Staging
Prognosis
Proto-Oncogene Proteins c-bcl-2 metabolism
Receptor, ErbB-2 metabolism
Receptors, Estrogen metabolism
Receptors, Progesterone metabolism
Retrospective Studies
Survival Rate
tau Proteins metabolism
Antineoplastic Combined Chemotherapy Protocols therapeutic use
Biomarkers, Tumor metabolism
Breast Neoplasms metabolism
Hepatocyte Nuclear Factor 3-alpha metabolism
Neoadjuvant Therapy
Neoplasm Recurrence, Local metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1880-4233
- Volume :
- 22
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Breast cancer (Tokyo, Japan)
- Publication Type :
- Academic Journal
- Accession number :
- 23771556
- Full Text :
- https://doi.org/10.1007/s12282-013-0482-2