Back to Search
Start Over
Genetic risk variants in African Americans with multiple sclerosis.
- Source :
-
Neurology [Neurology] 2013 Jul 16; Vol. 81 (3), pp. 219-27. Date of Electronic Publication: 2013 Jun 14. - Publication Year :
- 2013
-
Abstract
- Objectives: To assess the association of established multiple sclerosis (MS) risk variants in 3,254 African Americans (1,162 cases and 2,092 controls).<br />Methods: Human leukocyte antigen (HLA)-DRB1, HLA-DQB1, and HLA-A alleles were typed by molecular techniques. Single nucleotide polymorphism (SNP) genotyping was conducted for 76 MS-associated SNPs and 52 ancestry informative marker SNPs selected throughout the genome. Self-declared ancestry was refined by principal component analysis of the ancestry informative marker SNPs. An ancestry-adjusted multivariate model was applied to assess genetic associations.<br />Results: The following major histocompatibility complex risk alleles were replicated: HLA-DRB1*15:01 (odds ratio [OR] = 2.02 [95% confidence interval: 1.54-2.63], p = 2.50e-07), HLA-DRB1*03:01 (OR = 1.58 [1.29-1.94], p = 1.11e-05), as well as HLA-DRB1*04:05 (OR = 2.35 [1.26-4.37], p = 0.007) and the African-specific risk allele of HLA-DRB1*15:03 (OR = 1.26 [1.05-1.51], p = 0.012). The protective association of HLA-A*02:01 was confirmed (OR = 0.72 [0.55-0.93], p = 0.013). None of the HLA-DQB1 alleles were associated with MS. Using a significance threshold of p < 0.01, outside the major histocompatibility complex region, 8 MS SNPs were also found to be associated with MS in African Americans.<br />Conclusion: MS genetic risk in African Americans only partially overlaps with that of Europeans and could explain the difference of MS prevalence between populations.
- Subjects :
- Adult
Age of Onset
Alleles
Case-Control Studies
Female
Genetic Association Studies
Genotype
HLA-A Antigens genetics
HLA-DQ beta-Chains genetics
HLA-DRB1 Chains genetics
Humans
Male
Middle Aged
Multiple Sclerosis epidemiology
Black or African American genetics
Genetic Predisposition to Disease
Multiple Sclerosis genetics
Polymorphism, Single Nucleotide
Subjects
Details
- Language :
- English
- ISSN :
- 1526-632X
- Volume :
- 81
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Neurology
- Publication Type :
- Academic Journal
- Accession number :
- 23771490
- Full Text :
- https://doi.org/10.1212/WNL.0b013e31829bfe2f