Back to Search
Start Over
IL-4 -590C/T polymorphism and susceptibility to liver disease: a meta-analysis and meta-regression.
- Source :
-
DNA and cell biology [DNA Cell Biol] 2013 Aug; Vol. 32 (8), pp. 443-50. Date of Electronic Publication: 2013 Jun 15. - Publication Year :
- 2013
-
Abstract
- Interleukin-4 (IL-4) is a pleiotropic cytokine that plays an important role in the immune system. Emerging evidences have shown that the common polymorphism (-590C/T; rs2243250 C>T) in the IL-4 gene may play an important role in the development of various liver diseases, but individually published studies revealed inconclusive results. This meta-analysis aims to derive a more precise estimation of the association between the IL-4 -590C/T polymorphism and susceptibility to liver disease. A literature search of PubMed, Embase, Web of Science and China BioMedicine databases was conducted on articles published before January 1st, 2013. Crude odds ratio with 95% confidence intervals were calculated to assess the strength of this association. Ten case-control studies were assessed with a total 1,140 patients and 1,649 healthy controls. The meta-analysis results indicated that the IL-4 -590T polymorphism might increase the risks of hepatitis B (HBV) and hepatitis C (HCV) infections. Further subgroup analyses showed significant associations between the IL-4 -590T polymorphism and increased risks of liver diseases among Caucasian populations, but similar associations were not found among Asian populations. Univariate and multivariate meta-regression analyses showed that differences in ethnicity and clinical subtype are the major sources of heterogeneity. No publication bias was detected in this meta-analysis. In conclusion, the current meta-analysis indicates that the IL-4 -590T polymorphism may play an important role in increasing HBV and HCV infection risks, especially among Caucasian populations.
- Subjects :
- Adolescent
Adult
Aged
Aged, 80 and over
Algorithms
Case-Control Studies
Female
Genetic Association Studies statistics & numerical data
Genetic Predisposition to Disease ethnology
Hepatitis B epidemiology
Hepatitis B ethnology
Hepatitis B genetics
Hepatitis C epidemiology
Hepatitis C ethnology
Hepatitis C genetics
Humans
Liver Diseases epidemiology
Liver Diseases ethnology
Male
Middle Aged
Regression Analysis
White People genetics
White People statistics & numerical data
Young Adult
Interleukin-4 genetics
Liver Diseases genetics
Polymorphism, Single Nucleotide
Subjects
Details
- Language :
- English
- ISSN :
- 1557-7430
- Volume :
- 32
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- DNA and cell biology
- Publication Type :
- Academic Journal
- Accession number :
- 23768103
- Full Text :
- https://doi.org/10.1089/dna.2013.2020