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Peanut-specific IgE antibodies in asymptomatic Ghanaian children possibly caused by carbohydrate determinant cross-reactivity.
- Source :
-
The Journal of allergy and clinical immunology [J Allergy Clin Immunol] 2013 Sep; Vol. 132 (3), pp. 639-647. Date of Electronic Publication: 2013 Jun 12. - Publication Year :
- 2013
-
Abstract
- Background: The prevalence of peanut allergy has increased in developed countries, but little is known about developing countries with high peanut consumption and widespread parasitic infections.<br />Objective: We sought to investigate peanut allergy in Ghana.<br />Methods: In a cross-sectional survey among Ghanaian schoolchildren (n = 1604), data were collected on reported adverse reactions to peanut, peanut sensitization (serum specific IgE and skin reactivity), consumption patterns, and parasitic infections. In a subset (n = 43) IgE against Ara h 1, 2, 3, and 9 as well as cross-reactive carbohydrate determinants (CCDs) was measured by using ImmunoCAP. Cross-reactivity and biological activity were investigated by means of ImmunoCAP inhibition and basophil histamine release, respectively.<br />Results: Adverse reactions to peanut were reported in 1.5%, skin prick test reactivity in 2.0%, and IgE sensitization (≥0.35 kU/L) in 17.5% of participants. Moreover, 92.4% of those IgE sensitized to peanut (≥0.35 kU/L) had negative peanut skin prick test responses. Schistosoma haematobium infection was positively associated with IgE sensitization (adjusted odds ratio, 2.29; 95% CI, 1.37-3.86). In the subset IgE titers to Ara h 1, 2, 3, and 9 were low (<1.3 kU/L), except for 6 moderately strong reactions to Ara h 9. IgE against peanut was strongly correlated with IgE against CCDs (r = 0.89, P < .0001) and could be almost completely inhibited by CCDs, as well as S haematobium soluble egg antigen. Moreover, IgE to peanut showed poor biological activity.<br />Conclusions: Parasite-induced IgE against CCDs might account largely for high IgE levels to peanut in our study population of Ghanaian schoolchildren. No evidence of IgE-mediated peanut allergy was found.<br /> (Copyright © 2013 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved.)
- Subjects :
- Allergens immunology
Antigens, Plant immunology
Basophils immunology
Child
Cross Reactions
Female
Ghana epidemiology
Histamine Release
Humans
Male
Peanut Hypersensitivity epidemiology
Schistosomiasis haematobia epidemiology
Skin Tests
Arachis immunology
Carbohydrates immunology
Immunoglobulin E blood
Peanut Hypersensitivity immunology
Schistosomiasis haematobia immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1097-6825
- Volume :
- 132
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- The Journal of allergy and clinical immunology
- Publication Type :
- Academic Journal
- Accession number :
- 23763976
- Full Text :
- https://doi.org/10.1016/j.jaci.2013.04.023