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Immunity of human epithelial ovarian carcinoma: the paradigm of immune suppression in cancer.
- Source :
-
Journal of translational medicine [J Transl Med] 2013 Jun 13; Vol. 11, pp. 147. Date of Electronic Publication: 2013 Jun 13. - Publication Year :
- 2013
-
Abstract
- Epithelial ovarian cancer (EOC) is a significant cause of cancer-related mortality in women, and there has been no substantial decrease in the death rates due to EOC in the last three decades. Thus, basic knowledge regarding ovarian tumor cell biology is urgently needed to allow the development of innovative treatments for EOC. Traditionally, EOC has not been considered an immunogenic tumor, but there is evidence of an immune response to EOC in patients. Clinical data demonstrate that an antitumor immune response and immune evasion mechanisms are correlated with a better and lower survival, respectively, providing evidence for the immunoediting hypothesis in EOC. This review focuses on the immune response and immune suppression in EOC. The immunological roles of chemotherapy and surgery in EOC are also described. Finally, we detail pilot data supporting the efficiency of immunotherapy in the treatment of EOC and the emerging concept that immunomodulation aimed at counteracting the immunosuppressive microenvironment must be associated with immunotherapy strategies.
- Subjects :
- Carcinoma mortality
Cell Line, Tumor
Female
Gene Expression Regulation, Neoplastic
Humans
Immunotherapy methods
Neoplasms, Glandular and Epithelial mortality
Ovarian Neoplasms mortality
Treatment Outcome
Carcinoma immunology
Immune Tolerance
Neoplasms, Glandular and Epithelial immunology
Ovarian Neoplasms immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1479-5876
- Volume :
- 11
- Database :
- MEDLINE
- Journal :
- Journal of translational medicine
- Publication Type :
- Academic Journal
- Accession number :
- 23763830
- Full Text :
- https://doi.org/10.1186/1479-5876-11-147