Ligations from tyrosine isopeptides via 12- to 19-membered cyclic transition states.

Authors :: Popov V
Panda SS
Katritzky AR
Source :: The Journal of organic chemistry [J Org Chem] 2013 Aug 02; Vol. 78 (15), pp. 7455-61. Date of Electronic Publication: 2013 Jul 19.
Publication Year :: 2013
Abstract: Efficient syntheses of O-acyl Tyr-peptides allow chemical long-range ligation (O-acyl to N-acyl transfer) via each of 12- to 19-membered cyclic transition states. The results represent the first examples of successful isopeptide ligations starting from O-acyl Tyr-peptides.

Subjects :: Molecular Structure
Peptides chemistry
Peptides chemical synthesis
Tyrosine chemistry

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