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CTX-M-123, a novel hybrid of the CTX-M-1 and CTX-M-9 Group β-lactamases recovered from Escherichia coli isolates in China.
- Source :
-
Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2013 Aug; Vol. 57 (8), pp. 4068-71. Date of Electronic Publication: 2013 Jun 10. - Publication Year :
- 2013
-
Abstract
- The chimeric bla(CTX-M-123) gene was identified in two ceftazidime-resistant Escherichia coli isolates from animals in different Chinese provinces. Like other CTX-M-1/9 group hybrids (CTX-M-64 and CTX-M-132), the ends (amino acids 1 to 135 and 234 to 291) of CTX-M-123 match CTX-M-15 while the central part (122 to 241) matches CTX-M-14. bla(CTX-M-123) is carried on related, but not identical, ~90-kb IncI1 plasmids in the two isolates, and one isolate simultaneously carries the group 1 blaCTX-M-55 gene on an additional IncI2 plasmid.
- Subjects :
- Amino Acid Sequence
Animals
Bacterial Proteins genetics
Bacterial Proteins metabolism
Base Sequence
Ceftazidime pharmacology
China
Escherichia coli drug effects
Escherichia coli genetics
Escherichia coli Proteins classification
Escherichia coli Proteins genetics
Homologous Recombination
Microbial Sensitivity Tests
Molecular Sequence Data
Mutant Chimeric Proteins genetics
Plasmids genetics
Plasmids metabolism
beta-Lactamases classification
beta-Lactamases genetics
Escherichia coli enzymology
Escherichia coli Proteins metabolism
Genes, Bacterial
Mutant Chimeric Proteins metabolism
beta-Lactamases metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1098-6596
- Volume :
- 57
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Antimicrobial agents and chemotherapy
- Publication Type :
- Academic Journal
- Accession number :
- 23752509
- Full Text :
- https://doi.org/10.1128/AAC.00541-13