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Correlation of staging systems to survival in patients with resected hilar cholangiocarcinoma.
- Source :
-
American journal of surgery [Am J Surg] 2013 Aug; Vol. 206 (2), pp. 159-65. Date of Electronic Publication: 2013 Jun 06. - Publication Year :
- 2013
-
Abstract
- Background: We aimed to identify staging parameters associated with survival in patients with hilar cholangiocarcinoma.<br />Methods: Clinicopathologic characteristics were obtained retrospectively for all resected patients with Bismuth-Corlette III cholangiocarcinoma between 1993 and 2011. Patients were stratified by the American Joint Commission on Cancer (AJCC) (7th edition) and Memorial Sloan-Kettering Cancer Center (MSKCC) staging systems. Survival analyses tested the effects of clinicopathologic factors and staging covariates on recurrence-free and overall survival.<br />Results: Eighty patients (mean age 63 ± 11 years, 63% male) underwent anatomic hepatectomy with bile duct resection/reconstruction for Bismuth-Corlette IIIa (53%) and IIIb (47%) cholangiocarcinoma. The median follow-up was 26 months (interquartile range = 12 to 50 months), and the median time to recurrence was 15 months (interquartile range = 6 to 38 months). Neither AJCC nor MSKCC staging systems were associated with recurrence-free survival (all P ≥ .059). MSKCC T-stage but not the AJCC staging system was associated with overall survival (P ≤ .026).<br />Conclusions: MSKCC T-stage classification but not AJCC staging is independently associated with overall survival for patients after resection of hilar cholangiocarcinoma.<br /> (Copyright © 2013 Elsevier Inc. All rights reserved.)
- Subjects :
- Aged
Analysis of Variance
Bile Duct Neoplasms surgery
Cholangiocarcinoma surgery
Disease-Free Survival
Female
Humans
Kaplan-Meier Estimate
Male
Middle Aged
Neoplasm Grading
Predictive Value of Tests
Prognosis
Proportional Hazards Models
Retrospective Studies
Bile Duct Neoplasms mortality
Bile Duct Neoplasms pathology
Bile Ducts, Intrahepatic pathology
Bile Ducts, Intrahepatic surgery
Cholangiocarcinoma mortality
Cholangiocarcinoma pathology
Hepatectomy methods
Neoplasm Staging methods
Subjects
Details
- Language :
- English
- ISSN :
- 1879-1883
- Volume :
- 206
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- American journal of surgery
- Publication Type :
- Academic Journal
- Accession number :
- 23746658
- Full Text :
- https://doi.org/10.1016/j.amjsurg.2012.11.020