Chemoselective benzylation of unprotected anthranilic acids with benzhydryl alcohols by water-soluble Au(III)/TPPMS in water.

Authors :: Hikawa H
Suzuki H
Yokoyama Y
Azumaya I
Source :: The Journal of organic chemistry [J Org Chem] 2013 Jul 05; Vol. 78 (13), pp. 6714-20. Date of Electronic Publication: 2013 Jun 18.
Publication Year :: 2013
Abstract: A novel and efficient method for the benzylation of unprotected anthranilic acids with benzhydryl alcohols using water-soluble Au(III)/TPPMS in water is developed. Water plays an important role in our catalytic system. This new protocol could be used for not only N-benzylation, but also chemoselective C-benzylation by the Friedel-Crafts reaction.

Subjects :: Catalysis
Molecular Structure
Solubility
Water chemistry
Alcohols chemistry
Benzenesulfonates chemistry
Benzhydryl Compounds chemistry
Gold chemistry
Phosphines chemistry
ortho-Aminobenzoates chemistry

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