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Adult renal mesenchymal stem cell-like cells contribute to juxtaglomerular cell recruitment.
- Source :
-
Journal of the American Society of Nephrology : JASN [J Am Soc Nephrol] 2013 Jul; Vol. 24 (8), pp. 1263-73. Date of Electronic Publication: 2013 Jun 06. - Publication Year :
- 2013
-
Abstract
- The renin-angiotensin-aldosterone system (RAAS) regulates BP and salt-volume homeostasis. Juxtaglomerular (JG) cells synthesize and release renin, which is the first and rate-limiting step in the RAAS. Intense pathologic stresses cause a dramatic increase in the number of renin-producing cells in the kidney, termed JG cell recruitment, but how this occurs is not fully understood. Here, we isolated renal CD44(+) mesenchymal stem cell (MSC)-like cells and found that they differentiated into JG-like renin-expressing cells both in vitro and in vivo. Sodium depletion and captopril led to activation and differentiation of these cells into renin-expressing cells in the adult kidney. In summary, CD44(+) MSC-like cells exist in the adult kidney and can differentiate into JG-like renin-producing cells under conditions that promote JG cell recruitment.
- Subjects :
- Animals
Cell Differentiation drug effects
Juxtaglomerular Apparatus metabolism
Kidney metabolism
Male
Mice
Mice, Inbred C57BL
Renin-Angiotensin System drug effects
Adult Stem Cells metabolism
Captopril pharmacology
Cell Differentiation physiology
Juxtaglomerular Apparatus cytology
Kidney cytology
Mesenchymal Stem Cells metabolism
Renin metabolism
Renin-Angiotensin System physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1533-3450
- Volume :
- 24
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Journal of the American Society of Nephrology : JASN
- Publication Type :
- Academic Journal
- Accession number :
- 23744888
- Full Text :
- https://doi.org/10.1681/ASN.2012060596