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Effects of bioflavonoid ternatin on liver regeneration and oxidative stress in rats.
- Source :
-
Acta cirurgica brasileira [Acta Cir Bras] 2013 Jun; Vol. 28 (6), pp. 435-40. - Publication Year :
- 2013
-
Abstract
- Purpose: To evaluate the effect of bioflavonoid ternatin (TRT) on rat liver regeneration and oxidative stress after 70% partial hepatectomy (PH).<br />Methods: Thirty six young male Wistar rats were randomly assigned to two groups of 18 animals each - control (G1) and experimental (G2) - and were submitted to PH under inhalatory diethylether anesthesia. G1 rats received daily intraperitoneal (ip) injections of saline (NaCl 0.9% solution) 0.1 mL/kg for 14 days; G2 animals received daily ip injections of TRT 0.1% 1.0mg/kg for 14 days. At 36h (T1), 168h (T2) and 336h (T3) post-PH timepoints, a subgroup of six rats in each group was chosen in a randomized way to complementary hepatectomy (CH) and blood samples haversting. Collected material was saved for laboratory analysis (total bilirubin (TB), D-Glucose, glutathione (GSH) and thiobarbituric acid reactive substances (TBARS) and assessment of liver regeneration.<br />Results: TRT induced a significant decrease in liver and plasma GSH concentrations; liver regeneration process was not affected. TRT promoted a significant decrease in blood glucose levels 168h after partial hepatectomy compared with controls. TB levels remained unchanged.<br />Conclusion: Intraperitoneal bioflavonoid ternatin injection in partially hepatectomized rats induces a decrease in oxidative stress and a significant hypoglycemic state, but does not promote any change in the evolution of liver regeneration.
- Subjects :
- Animals
Antioxidants pharmacology
Bilirubin blood
Glucose analysis
Glutathione blood
Hepatectomy methods
Injections, Intraperitoneal
Liver metabolism
Liver Regeneration physiology
Male
Organ Size
Random Allocation
Rats
Rats, Wistar
Thiobarbituric Acid Reactive Substances analysis
Time Factors
Flavonoids pharmacology
Liver Regeneration drug effects
Oxidative Stress drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1678-2674
- Volume :
- 28
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Acta cirurgica brasileira
- Publication Type :
- Academic Journal
- Accession number :
- 23743681
- Full Text :
- https://doi.org/10.1590/s0102-86502013000600006