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Application of the single blood sample method to estimate feline glomerular filtration rate in a clinically relevant situation.
- Source :
-
Journal of feline medicine and surgery [J Feline Med Surg] 2013 Dec; Vol. 15 (12), pp. 1119-22. Date of Electronic Publication: 2013 Jun 04. - Publication Year :
- 2013
-
Abstract
- To compare glomerular filtration rate (GFR) estimated by a single blood sample method, the non-ionic contrast medium iodixanol (40 mg I/kg) and the standard GFR tracer inulin (50 mg/kg) were co-administered as a bolus intravenous injection to 12 cats, followed by blood collection 60 and 90 mins later. Serum iodixanol and inulin concentrations were measured separately by high-performance liquid chromatography and colourimetric assay. A correlation (r = 0.90, P <0.01) was noted between GFR values estimated by the single-blood-sample method using iodixanol and inulin, indicating that this procedure can apply to feline GFR estimates, even if different GFR tracers are used. In a feline kidney transplantation study, the GFR was monitored subsequently by this simplified iodixanol method throughout a 750-day observation period with no adverse reactions. The results demonstrate that the simplified method, including the volume of distribution, can be used as an alternative or expedient tool in a clinically relevant situation.
Details
- Language :
- English
- ISSN :
- 1532-2750
- Volume :
- 15
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Journal of feline medicine and surgery
- Publication Type :
- Academic Journal
- Accession number :
- 23735674
- Full Text :
- https://doi.org/10.1177/1098612X13492165