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Long-term clinical outcomes in patients with refractory uveitis associated with Behçet disease treated with infliximab.
- Source :
-
Ocular immunology and inflammation [Ocul Immunol Inflamm] 2013 Dec; Vol. 21 (6), pp. 468-74. Date of Electronic Publication: 2013 Jun 04. - Publication Year :
- 2013
-
Abstract
- Purpose: To assess long-term efficacy and safety of infliximab for refractory Behçet disease (BD) uveitis and to evaluate the effect of withdrawal of infliximab after achieving long-term remission.<br />Methods: Retrospective study of 19 patients.<br />Results: Mean follow-up was 44.1 ± 36.5 months and mean number of infliximab infusions was 21.6 ± 14.6. At end of follow-up, there was significant improvement of visual acuity and reduction of central macular thickness. All patients achieved remission, 14 of whom were able to discontinue corticosteroids. Ten patients developed autoantibodies and 1 patient developed infusion reactions. Eight eyes underwent intraocular surgery without exacerbation of quiescent uveitis. After achieving complete remission, 5 patients discontinued infliximab and maintained remission during a mean of 24.6 ± 5.5 months.<br />Conclusions: Infliximab is effective and safe for long-term treatment for refractory BD uveitis. Repeated infusions are required to maintain long-term remission, which may be sustained despite withdrawal of infliximab. Induction of autoantibodies is common.
- Subjects :
- Adolescent
Adult
Anti-Inflammatory Agents, Non-Steroidal administration & dosage
Behcet Syndrome diagnosis
Behcet Syndrome drug therapy
Child
Female
Fluorescein Angiography
Follow-Up Studies
Fundus Oculi
Humans
Infliximab
Infusions, Intravenous
Male
Remission Induction
Retrospective Studies
Time Factors
Tomography, Optical Coherence
Treatment Outcome
Tumor Necrosis Factor-alpha antagonists & inhibitors
Uveitis, Posterior diagnosis
Uveitis, Posterior etiology
Visual Acuity
Young Adult
Antibodies, Monoclonal administration & dosage
Behcet Syndrome complications
Uveitis, Posterior drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1744-5078
- Volume :
- 21
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Ocular immunology and inflammation
- Publication Type :
- Academic Journal
- Accession number :
- 23734940
- Full Text :
- https://doi.org/10.3109/09273948.2013.779727