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AlCl3-mediated hydroarylation-heteroarylation in a single pot: a direct access to densely functionalized olefins of pharmacological interest.
- Source :
-
Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2013 Jul 18; Vol. 49 (56), pp. 6268-70. - Publication Year :
- 2013
-
Abstract
- An unprecedented AlCl3-mediated method has been developed involving aromatic C-H bond addition to an alkyne and heteroarylation of an arene in a single pot leading to densely functionalized novel olefins, e.g. 2-(2,2-diarylvinyl)-3-arylquinoxalines, as potential inhibitors of sirtuins.
- Subjects :
- Aluminum Chloride
Animals
Antineoplastic Agents chemical synthesis
Antineoplastic Agents chemistry
Cell Line, Tumor
Cell Proliferation drug effects
Dose-Response Relationship, Drug
Drug Screening Assays, Antitumor
Enzyme Inhibitors chemical synthesis
Enzyme Inhibitors chemistry
Humans
Models, Molecular
Molecular Structure
Quinoxalines chemical synthesis
Quinoxalines chemistry
Sirtuins metabolism
Structure-Activity Relationship
Zebrafish
Alkenes chemistry
Aluminum Compounds chemistry
Antineoplastic Agents pharmacology
Chlorides chemistry
Embryo, Nonmammalian drug effects
Enzyme Inhibitors pharmacology
Quinoxalines pharmacology
Sirtuins antagonists & inhibitors
Subjects
Details
- Language :
- English
- ISSN :
- 1364-548X
- Volume :
- 49
- Issue :
- 56
- Database :
- MEDLINE
- Journal :
- Chemical communications (Cambridge, England)
- Publication Type :
- Academic Journal
- Accession number :
- 23732749
- Full Text :
- https://doi.org/10.1039/c3cc42840k