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Idarubicin appears equivalent to dose-intense daunorubicin for remission induction in patients with acute myeloid leukemia.

Authors :
Trifilio S
Zhou Z
Mehta J
Czerniak C
Pi J
Greenberg D
Koslosky M
Pantiru M
Altman J
Source :
Leukemia research [Leuk Res] 2013 Aug; Vol. 37 (8), pp. 868-71. Date of Electronic Publication: 2013 May 31.
Publication Year :
2013

Abstract

Daunorubicin has historically been considered the anthracycline of choice at many cancer centers for the treatment of acute myeloid leukemia (AML). Drug shortages have required the substitution of daunorubicin with idarubicin. Randomized studies have shown idarubicin (10-12mg/m(2)) to be comparable or superior to standard dose daunorubicin (45-60mg/m(2)) for achieving complete remission (CR). Whether these results can be extrapolated to dose-intense daunorubicin (90mg/m(2)), recently shown to improve CR rates when compared to standard daunorubicin doses remains uncertain. This observational study was conducted at Northwestern Memorial Hospital (NMH) to compare CR rates. The results suggest idarubicin is equivalent to daunorubicin, and for some subsets of patients, idarubicin may have superior CR rates.<br /> (Copyright © 2013 Elsevier Ltd. All rights reserved.)

Details

Language :
English
ISSN :
1873-5835
Volume :
37
Issue :
8
Database :
MEDLINE
Journal :
Leukemia research
Publication Type :
Academic Journal
Accession number :
23726414
Full Text :
https://doi.org/10.1016/j.leukres.2013.04.009