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Aromatase inhibitors with or without gonadotropin-releasing hormone analogue in metastatic male breast cancer: a case series.
- Source :
-
British journal of cancer [Br J Cancer] 2013 Jun 11; Vol. 108 (11), pp. 2259-63. Date of Electronic Publication: 2013 May 30. - Publication Year :
- 2013
-
Abstract
- Background: Data regarding the safety and effectiveness of aromatase inhibitors (AIs) as monotherapy or combined with gonadotropin-releasing hormone (GnRH) analogue in male breast cancer are scarce.<br />Methods: In this retrospective chart review, cases of male breast cancer patients treated with AIs with or without a GnRH analogue were evaluated.<br />Results: Twenty-three men were included into this case series. Aromatase inhibitors in combination with or without a GnRH analogue were given as first-line therapy in 60.9% and as second-line therapy in 39.1% of patients, respectively. All patients had visceral metastases, whereas in five of them bone lesions coexisted. In all cases AIs were tolerated well, and no case of grade 3 and 4 adverse events was reported. A partial response was observed in 26.1% of patients and stable disease in 56.5%. Median overall survival (OS) was 39 months and median progression-free survival (PFS) was 13 months. Regarding OS and PFS, no significant effects of GnRH analogue co-administration or type of AI were noted.<br />Conclusion: Our study shows that AIs with or without GnRH analogues may represent an effective and safe treatment option for hormone-receptor positive, pretreated, metastatic, male breast cancer patients.
- Subjects :
- Aged
Antineoplastic Agents, Hormonal administration & dosage
Aromatase Inhibitors administration & dosage
Breast Neoplasms, Male pathology
Goserelin administration & dosage
Humans
Kaplan-Meier Estimate
Male
Middle Aged
Neoplasm Metastasis
Retrospective Studies
Antineoplastic Combined Chemotherapy Protocols therapeutic use
Aromatase Inhibitors therapeutic use
Breast Neoplasms, Male drug therapy
Gonadotropin-Releasing Hormone analogs & derivatives
Subjects
Details
- Language :
- English
- ISSN :
- 1532-1827
- Volume :
- 108
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- British journal of cancer
- Publication Type :
- Academic Journal
- Accession number :
- 23722469
- Full Text :
- https://doi.org/10.1038/bjc.2013.255