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Prevention of T-2 toxin-induced morphologic effects in the rat by highly activated charcoal.
- Source :
-
Archives of toxicology [Arch Toxicol] 1990; Vol. 64 (3), pp. 251-3. - Publication Year :
- 1990
-
Abstract
- The efficacy of a highly activated charcoal in preventing the morphologic effects of T-2 toxin was examined in female rats. T-2 toxin at 25 mg/kg (6 x LD50) was given orally to all rats. Half the rats also received the charcoal, at a dose of 9 ml/kg and a concentration of 104 mg/ml, while the other half received water. A charcoal-treated rat (T-2 toxin + charcoal) was killed at the time of death of each positive control animal (T-2 toxin alone). Severe necrosis was seen in the spleen, thymus, stomach, small intestine, liver and adrenal glands of the positive controls (T-2 toxin alone). Lesions were absent or minimal in the paired charcoal-treated rats (T-2 toxin + charcoal).
Details
- Language :
- English
- ISSN :
- 0340-5761
- Volume :
- 64
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Archives of toxicology
- Publication Type :
- Academic Journal
- Accession number :
- 2372237
- Full Text :
- https://doi.org/10.1007/BF02010733