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Prevention of T-2 toxin-induced morphologic effects in the rat by highly activated charcoal.

Authors :
Bratich PM
Buck WB
Haschek WM
Source :
Archives of toxicology [Arch Toxicol] 1990; Vol. 64 (3), pp. 251-3.
Publication Year :
1990

Abstract

The efficacy of a highly activated charcoal in preventing the morphologic effects of T-2 toxin was examined in female rats. T-2 toxin at 25 mg/kg (6 x LD50) was given orally to all rats. Half the rats also received the charcoal, at a dose of 9 ml/kg and a concentration of 104 mg/ml, while the other half received water. A charcoal-treated rat (T-2 toxin + charcoal) was killed at the time of death of each positive control animal (T-2 toxin alone). Severe necrosis was seen in the spleen, thymus, stomach, small intestine, liver and adrenal glands of the positive controls (T-2 toxin alone). Lesions were absent or minimal in the paired charcoal-treated rats (T-2 toxin + charcoal).

Details

Language :
English
ISSN :
0340-5761
Volume :
64
Issue :
3
Database :
MEDLINE
Journal :
Archives of toxicology
Publication Type :
Academic Journal
Accession number :
2372237
Full Text :
https://doi.org/10.1007/BF02010733