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[Gestational pemphigoid].

[Gestational pemphigoid].

Authors :
Huilaja L
Mäkikallio K
Tasanen K
Source :
Duodecim; laaketieteellinen aikakauskirja [Duodecim] 2013; Vol. 129 (7), pp. 731-8.
Publication Year :
2013

Abstract

Gestational pemphigoid is a rare pruritic bullous pregnancy associated dermatosis caused by autoantibodies against placental and dermal collagen XVII. Clinically, it is characterized by severe pruritus and blisters on abdominal skin and extremities. Immunofluorescence analysis of perilesional skin is used in the diagnostics and maternal serum BP180-levels reflect the disease activity. Topical steroids and antihistamins usually relieve mild symptoms, but in severe cases oral corticosteroid is the drug-of-choice. Spontaneous recovery is common after parturition but this disease typically recurs in the following pregnancies. Due to the associated risk of prematurity and fetal growth restriction, prenatal monitoring jointly by a dermatologist and an obstetrician is recommended.

Details

Language :
Finnish
ISSN :
0012-7183
Volume :
129
Issue :
7
Database :
MEDLINE
Journal :
Duodecim; laaketieteellinen aikakauskirja
Publication Type :
Academic Journal
Accession number :
23720942