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Transoral laser microsurgery in treatment of pT2 and pT3 glottic laryngeal squamous cell carcinoma - results of 391 patients.
- Source :
-
Head & neck [Head Neck] 2014 Jun; Vol. 36 (6), pp. 859-66. Date of Electronic Publication: 2013 Sep 02. - Publication Year :
- 2014
-
Abstract
- Background: The purpose of this study was to evaluate oncological and functional results of transoral laser microsurgery (TLM) in patients with T2 and T3 glottic laryngeal squamous cell carcinoma (SCC).<br />Methods: A retrospective chart analysis was carried out. Cases were classified into categories pT2a, pT2b, and pT3. Treatment was exclusively TLM ±â€‰selective neck dissection and adjuvant (chemo)radiotherapy.<br />Results: Three hundred ninety-one patients were treated by TLM; 142 cases were category pT2a, 127 were pT2b, and 122 were pT3. Median follow-up was 71 months. Five-year overall, recurrence-free, and disease specific survival rates were 72.2%, 76.4%, and 93.2% for pT2a tumors, 64.9%, 57.3%, and 83.9% for pT2b tumors, and 58.6%, 57.8%, and 84.1% for pT3 tumors, respectively. Larynx preservation was achieved in 93% (pT2a) and 83% (pT2b and pT3).<br />Conclusion: Results are comparable to open partial or total laryngectomy and superior to primary (chemo)radiotherapy. TLM results in a lower morbidity and superior function compared to standard treatment.<br /> (© 2013 Wiley Periodicals, Inc.)
- Subjects :
- Adolescent
Adult
Aged
Aged, 80 and over
Carcinoma, Squamous Cell mortality
Carcinoma, Squamous Cell pathology
Carcinoma, Squamous Cell therapy
Chemoradiotherapy, Adjuvant methods
Female
Follow-Up Studies
Glottis physiopathology
Glottis surgery
Humans
Kaplan-Meier Estimate
Laryngeal Neoplasms mortality
Laryngeal Neoplasms pathology
Laryngeal Neoplasms therapy
Male
Medical Records Systems, Computerized
Microsurgery methods
Middle Aged
Neck Dissection
Neoplasm Invasiveness
Neoplasm Recurrence, Local mortality
Neoplasm Recurrence, Local therapy
Neoplasm Staging
Recovery of Function
Retrospective Studies
Salvage Therapy methods
Treatment Outcome
Carcinoma, Squamous Cell surgery
Laryngeal Neoplasms surgery
Laryngectomy methods
Laser Therapy methods
Natural Orifice Endoscopic Surgery methods
Neoplasm Recurrence, Local surgery
Organ Sparing Treatments methods
Subjects
Details
- Language :
- English
- ISSN :
- 1097-0347
- Volume :
- 36
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Head & neck
- Publication Type :
- Academic Journal
- Accession number :
- 23720321
- Full Text :
- https://doi.org/10.1002/hed.23389